Annual report pursuant to Section 13 and 15(d)

Revenue - F. Hoffmann-La Roche Ltd. and Hoffman-La Roche Inc. (Details)

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Revenue - F. Hoffmann-La Roche Ltd. and Hoffman-La Roche Inc. (Details) - USD ($)
$ in Thousands
1 Months Ended 12 Months Ended
Dec. 31, 2015
Dec. 31, 2017
Dec. 31, 2016
Deferred Revenue Arrangement [Line Items]      
Upfront license payment   $ 11,285 $ 2,736
Roche      
Deferred Revenue Arrangement [Line Items]      
Deferred revenue   $ 1,500  
Roche | Upfront Payment      
Deferred Revenue Arrangement [Line Items]      
Upfront license payment $ 6,500    
Roche | Research and Development Services      
Deferred Revenue Arrangement [Line Items]      
Research collaboration agreement term 20 months    
Roche | Research and Development Services | Extension Term      
Deferred Revenue Arrangement [Line Items]      
Research collaboration agreement term 5 years