Annual report pursuant to Section 13 and 15(d)

Debt - Related Party Interest Expense Concerning Bridge Loan (Detail)

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Debt - Related Party Interest Expense Concerning Bridge Loan (Detail) - Bridge Loan [Member] - USD ($)
 12 Months Ended
Dec. 31, 2015
Dec. 31, 2014
Short-term Debt [Line Items]    
Interest expense related party $ 0 $ 204,110
Orbimed Private Investments III, LP [Member]    
Short-term Debt [Line Items]    
Interest expense related party 0 63,955
Global Life Science Ventures Funds [Member]    
Short-term Debt [Line Items]    
Interest expense related party 0 57,709
Gilde Europe Food & Agribusiness Fund B.V [Member]    
Short-term Debt [Line Items]    
Interest expense related party 0 54,158
Forbion B.V [Member]    
Short-term Debt [Line Items]    
Interest expense related party $ 0 $ 28,288