Pieris and Pfizer (formerly Seagen) Immuno-Oncology Collaboration

This collaboration aims to investigate several targeted, bispecific immuno-oncology treatments for solid tumors and blood cancers. Together, we will develop antibody-Anticalin fusion proteins that leverages Pieris’ suite of agonistic costimulatory Anticalin proteins and Pfizer’s portfolio of cancer targets and tumor-specific antibodies. The bispecific drugs will be designed to activate a patient’s immune cells locally in the tumor microenvironment.

Pipeline Chart

Immuno-Oncology

Candidate
Targets
Partner
Discovery
Preclinical
Phase 1
Phase 2
Candidate PRS-346/SGN-BB228
Targets

4-1BB/CD228

Partner

Discovery complete
Preclinical complete
Phase 1 in progress
Phase 2 not started
Candidate Candidate Seagen Programs‡
Targets

n.d.

Partner

Discovery in progress
Preclinical not started
Phase 1 not started
Phase 2 not started

‡ 2 active bispecific programs in collaboration with Pfizer in addition to PRS-346/SGN-BB228 listed above.